Cities are facing mayor challenges to handle transitions related to Energy, Mobility, Circular Economy, and Healthcare. Different systems that require a more integrated approach in terms of designing and implementing these innovative solutions. No longer top-down innovations but co-creation in close liaison with (future) citizen. Brainport Eindhoven has taken these challenges to develop a living lab that allows real time experiments in a new neighborhood where new technological and social innovations can be applied and tested in close alignment with its community members. This offers private companies a unique opportunity to test prototypes on their way towards market introduction. This helps to expand the successful model of Triple-Helix for innovation.